Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcγRII-dependent entry into B cells in vitro
Identifieur interne : 003B88 ( Main/Exploration ); précédent : 003B87; suivant : 003B89Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcγRII-dependent entry into B cells in vitro
Auteurs : YIU WING KAM [Hong Kong] ; Francois Kien [Hong Kong] ; Anjeanette Roberts [États-Unis] ; YAN CHUNG CHEUNG [Hong Kong] ; Elaine W. Lamirande [États-Unis] ; Leatrice Vogel [États-Unis] ; SHUI LING CHU [Hong Kong] ; Jane Tse [Hong Kong] ; Jeannette Guarner [États-Unis] ; Sherif R. Zaki [États-Unis] ; Kanta Subbarao [États-Unis] ; Malik Peiris [Hong Kong] ; Beatrice Nal [Hong Kong] ; Ralf Altmeyer [Singapour]Source :
- Vaccine [ 0264-410X ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Vaccine-induced antibodies can prevent or, in the case of feline infectious peritonitis virus, aggravate infections by coronaviruses. We investigated whether a recombinant native full-length S-protein trimer (triSpike) of severe acute respiratory syndrome coronavirus (SARS-CoV) was able to elicit a neutralizing and protective immune response in animals and analyzed the capacity of anti-S antibodies to mediate antibody-dependent enhancement (ADE) of virus entry in vitro and enhancement of replication in vivo. SARS-CoV-specific serum and mucosal immunoglobulins were readily detected in immunized animals. Serum IgG blocked binding of the S-protein to the ACE2 receptor and neutralized SARS-CoV infection in vitro. Entry into human B cell lines occurred in a FcγRII-dependent and ACE2-independent fashion indicating that ADE of virus entry is a novel cell entry mechanism of SARS-CoV. Vaccinated animals showed no signs of enhanced lung pathology or hepatitis and viral load was undetectable or greatly reduced in lungs following challenge with SARS-CoV. Altogether our results indicate that a recombinant trimeric S protein was able to elicit an efficacious protective immune response in vivo and warrant concern in the safety evaluation of a human vaccine against SARS-CoV.
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcγRII-dependent entry into B cells in vitro</title><author><name sortKey="Yiu Wing Kam" sort="Yiu Wing Kam" uniqKey="Yiu Wing Kam" last="Yiu Wing Kam">YIU WING KAM</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HKU-Pasteur Research Centre, 8 Sassoon Road</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>HKU-Pasteur Research Centre, 8 Sassoon Road</wicri:noRegion></affiliation></author><author><name sortKey="Kien, Francois" sort="Kien, Francois" uniqKey="Kien F" first="Francois" last="Kien">Francois Kien</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HKU-Pasteur Research Centre, 8 Sassoon Road</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>HKU-Pasteur Research Centre, 8 Sassoon Road</wicri:noRegion></affiliation></author><author><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Infectious Diseases, NIAID, National Institutes of Health, MSC-8007, 50 South Drive</s1><s2>Bethesda, MD 20892-8007</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Yan Chung Cheung" sort="Yan Chung Cheung" uniqKey="Yan Chung Cheung" last="Yan Chung Cheung">YAN CHUNG CHEUNG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Microbiology, The University of Hong Kong</s1><s3>HKG</s3><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Infectious Diseases, NIAID, National Institutes of Health, MSC-8007, 50 South Drive</s1><s2>Bethesda, MD 20892-8007</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Infectious Diseases, NIAID, National Institutes of Health, MSC-8007, 50 South Drive</s1><s2>Bethesda, MD 20892-8007</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Shui Ling Chu" sort="Shui Ling Chu" uniqKey="Shui Ling Chu" last="Shui Ling Chu">SHUI LING CHU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HKU-Pasteur Research Centre, 8 Sassoon Road</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>HKU-Pasteur Research Centre, 8 Sassoon Road</wicri:noRegion></affiliation></author><author><name sortKey="Tse, Jane" sort="Tse, Jane" uniqKey="Tse J" first="Jane" last="Tse">Jane Tse</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HKU-Pasteur Research Centre, 8 Sassoon Road</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>HKU-Pasteur Research Centre, 8 Sassoon Road</wicri:noRegion></affiliation></author><author><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R." last="Zaki">Sherif R. Zaki</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Infectious Diseases, NIAID, National Institutes of Health, MSC-8007, 50 South Drive</s1><s2>Bethesda, MD 20892-8007</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Microbiology, The University of Hong Kong</s1><s3>HKG</s3><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Nal, Beatrice" sort="Nal, Beatrice" uniqKey="Nal B" first="Beatrice" last="Nal">Beatrice Nal</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HKU-Pasteur Research Centre, 8 Sassoon Road</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>HKU-Pasteur Research Centre, 8 Sassoon Road</wicri:noRegion></affiliation></author><author><name sortKey="Altmeyer, Ralf" sort="Altmeyer, Ralf" uniqKey="Altmeyer R" first="Ralf" last="Altmeyer">Ralf Altmeyer</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>CombinatorX, 11 Biopolis Way, Helios #08-05/06</s1><s2>Singapore 128667</s2><s3>SGP</s3><sZ>14 aut.</sZ></inist:fA14><country>Singapour</country><wicri:noRegion>Singapore 128667</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0076955</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0076955 INIST</idno><idno type="RBID">Pascal:07-0076955</idno><idno type="wicri:Area/PascalFrancis/Corpus">000419</idno><idno type="wicri:Area/PascalFrancis/Curation">000570</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000400</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000400</idno><idno type="wicri:doubleKey">0264-410X:2007:Yiu Wing Kam:antibodies:against:trimeric</idno><idno type="wicri:Area/Main/Merge">003D47</idno><idno type="wicri:Area/Main/Curation">003B88</idno><idno type="wicri:Area/Main/Exploration">003B88</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcγRII-dependent entry into B cells in vitro</title><author><name sortKey="Yiu Wing Kam" sort="Yiu Wing Kam" uniqKey="Yiu Wing Kam" last="Yiu Wing Kam">YIU WING KAM</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HKU-Pasteur Research Centre, 8 Sassoon Road</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>HKU-Pasteur Research Centre, 8 Sassoon Road</wicri:noRegion></affiliation></author><author><name sortKey="Kien, Francois" sort="Kien, Francois" uniqKey="Kien F" first="Francois" last="Kien">Francois Kien</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HKU-Pasteur Research Centre, 8 Sassoon Road</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>HKU-Pasteur Research Centre, 8 Sassoon Road</wicri:noRegion></affiliation></author><author><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Infectious Diseases, NIAID, National Institutes of Health, MSC-8007, 50 South Drive</s1><s2>Bethesda, MD 20892-8007</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Yan Chung Cheung" sort="Yan Chung Cheung" uniqKey="Yan Chung Cheung" last="Yan Chung Cheung">YAN CHUNG CHEUNG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Microbiology, The University of Hong Kong</s1><s3>HKG</s3><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Infectious Diseases, NIAID, National Institutes of Health, MSC-8007, 50 South Drive</s1><s2>Bethesda, MD 20892-8007</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Infectious Diseases, NIAID, National Institutes of Health, MSC-8007, 50 South Drive</s1><s2>Bethesda, MD 20892-8007</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Shui Ling Chu" sort="Shui Ling Chu" uniqKey="Shui Ling Chu" last="Shui Ling Chu">SHUI LING CHU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HKU-Pasteur Research Centre, 8 Sassoon Road</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>HKU-Pasteur Research Centre, 8 Sassoon Road</wicri:noRegion></affiliation></author><author><name sortKey="Tse, Jane" sort="Tse, Jane" uniqKey="Tse J" first="Jane" last="Tse">Jane Tse</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HKU-Pasteur Research Centre, 8 Sassoon Road</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>HKU-Pasteur Research Centre, 8 Sassoon Road</wicri:noRegion></affiliation></author><author><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R." last="Zaki">Sherif R. Zaki</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Laboratory of Infectious Diseases, NIAID, National Institutes of Health, MSC-8007, 50 South Drive</s1><s2>Bethesda, MD 20892-8007</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Microbiology, The University of Hong Kong</s1><s3>HKG</s3><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, The University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Nal, Beatrice" sort="Nal, Beatrice" uniqKey="Nal B" first="Beatrice" last="Nal">Beatrice Nal</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HKU-Pasteur Research Centre, 8 Sassoon Road</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>HKU-Pasteur Research Centre, 8 Sassoon Road</wicri:noRegion></affiliation></author><author><name sortKey="Altmeyer, Ralf" sort="Altmeyer, Ralf" uniqKey="Altmeyer R" first="Ralf" last="Altmeyer">Ralf Altmeyer</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>CombinatorX, 11 Biopolis Way, Helios #08-05/06</s1><s2>Singapore 128667</s2><s3>SGP</s3><sZ>14 aut.</sZ></inist:fA14><country>Singapour</country><wicri:noRegion>Singapore 128667</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody</term><term>B-Lymphocyte</term><term>Glycoprotein</term><term>Hamster</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hamster</term><term>Anticorps</term><term>Glycoprotéine</term><term>Lymphocyte B</term><term>Syndrome respiratoire aigu sévère</term><term>Récepteur FcγII</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vaccine-induced antibodies can prevent or, in the case of feline infectious peritonitis virus, aggravate infections by coronaviruses. We investigated whether a recombinant native full-length S-protein trimer (triSpike) of severe acute respiratory syndrome coronavirus (SARS-CoV) was able to elicit a neutralizing and protective immune response in animals and analyzed the capacity of anti-S antibodies to mediate antibody-dependent enhancement (ADE) of virus entry in vitro and enhancement of replication in vivo. SARS-CoV-specific serum and mucosal immunoglobulins were readily detected in immunized animals. Serum IgG blocked binding of the S-protein to the ACE2 receptor and neutralized SARS-CoV infection in vitro. Entry into human B cell lines occurred in a FcγRII-dependent and ACE2-independent fashion indicating that ADE of virus entry is a novel cell entry mechanism of SARS-CoV. Vaccinated animals showed no signs of enhanced lung pathology or hepatitis and viral load was undetectable or greatly reduced in lungs following challenge with SARS-CoV. Altogether our results indicate that a recombinant trimeric S protein was able to elicit an efficacious protective immune response in vivo and warrant concern in the safety evaluation of a human vaccine against SARS-CoV.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>Singapour</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Maryland</li></region></list><tree><country name="Hong Kong"><noRegion><name sortKey="Yiu Wing Kam" sort="Yiu Wing Kam" uniqKey="Yiu Wing Kam" last="Yiu Wing Kam">YIU WING KAM</name></noRegion><name sortKey="Kien, Francois" sort="Kien, Francois" uniqKey="Kien F" first="Francois" last="Kien">Francois Kien</name><name sortKey="Nal, Beatrice" sort="Nal, Beatrice" uniqKey="Nal B" first="Beatrice" last="Nal">Beatrice Nal</name><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><name sortKey="Shui Ling Chu" sort="Shui Ling Chu" uniqKey="Shui Ling Chu" last="Shui Ling Chu">SHUI LING CHU</name><name sortKey="Tse, Jane" sort="Tse, Jane" uniqKey="Tse J" first="Jane" last="Tse">Jane Tse</name><name sortKey="Yan Chung Cheung" sort="Yan Chung Cheung" uniqKey="Yan Chung Cheung" last="Yan Chung Cheung">YAN CHUNG CHEUNG</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name></region><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R." last="Zaki">Sherif R. Zaki</name></country><country name="Singapour"><noRegion><name sortKey="Altmeyer, Ralf" sort="Altmeyer, Ralf" uniqKey="Altmeyer R" first="Ralf" last="Altmeyer">Ralf Altmeyer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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